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Mol. Hum. Reprod. Advance Access published online on February 17, 2009
Molecular Human Reproduction, doi:10.1093/molehr/gap009
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© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

Embryo-uterine cross-talk during implantation: The role of Wnt signaling

Qi Chen1,2,3, Ying Zhang1,2,3, Jinhua Lu1,2, Qiang Wang1,2, Shuangjie Wang1,2, Yujing Cao1, Haibin Wang1,4 and Enkui Duan1,4

1State Key Laboratory of Reproductive Biology, Institute of Zoology, Chinese Academy of Sciences, Beijing, 100101, China 2Graduate School of the Chinese Academy of Sciences, Beijing, 100039, China

4 Correspondence address. E-mail: hbwang{at}ioz.ac.cn or duane{at}ioz.ac.cn

During mammalian pregnancy, it has been demonstrated that the quality of embryo implantation determines the quality of ongoing pregnancy and fetal development. Recent studies have provided increasing evidence that differential Wnt signaling plays diverse roles in multiple peri-implantation events. This review focuses on recent progress on various aspects of Wnt signalling in preimplantation embryo development, blastocyst activation for implantation and uterine decidualization. Future studies with conditional deletion of Wnt family members are hoped to provide deeper insight on the pathophysiological significance of Wnt proteins on early pregnancy events.

Key Words: Wnt signaling/preimplantation embryo development/blastocyst activation/implantation/decidualization

3 These authors contribute equally

Submitted on November 30, 2008; resubmitted on January 10, 2009; accepted on January 28, 2009.


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