Skip Navigation



Mol. Hum. Reprod. Advance Access published online on May 12, 2009
Molecular Human Reproduction, doi:10.1093/molehr/gap032
This Article
Right arrow Advance Access manuscript (PDF)
Right arrow All Versions of this Article:
15/7/443    most recent
gap032v1
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrowRequest Permissions
Google Scholar
Right arrow Articles by Peterson, H.
Right arrow Articles by Kivinen, K.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Peterson, H.
Right arrow Articles by Kivinen, K.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

© The Author 2009. Published by Oxford University Press on behalf of the European Society of Human Reproduction and Embryology. All rights reserved. For Permissions, please email: journals.permissions@oxfordjournals.org

ROCK2 allelic variants are not associated with preeclampsia susceptibility in the Finnish population

H. Peterson1, H. Laivuori2,3, E. Kerkelä4, H. Jiao1, L. Hiltunen6, S. Heino5, I. Tiala2, S. Knuutila5, V. Rasi6, J. Kere1,2,7 and K. Kivinen1

1Department of Biosciences and Nutrition, Karolinska Institutet, Stockholm, Sweden 2Department of Medical Genetics, University of Helsinki, and Folkhälsan Institute of Genetics, Helsinki, Finland 3Department of Clinical Genetics, Helsinki University Central Hospital, Finland 4Institute for Regenerative Medicine Regea, University of Tampere and University hospital of Tampere, Finland 5Laboratory of Cytomolecular Genetics, University of Helsinki, Finland 6Finnish Red Cross Blood Service, Helsinki, Finland

7 To whom correspondence should be addressed at: Department of Biosciences and Nutrition, Karolinska Institutet, S-141 57 Huddinge, Sweden. E-mail: juha.kere{at}ki.se

The Rho-associated coiled-coil protein kinase 2 (ROCK2) gene has been suggested to associate with general hypertension and is therefore a plausible functional candidate gene for preeclampsia. ROCK2 maps to chromosome 2p25 that we have implicated previously in a linkage study of preeclampsia. We have re-sequenced exons and putative promoter region of ROCK2 in up to 30 preeclampsia patients and 22 controls, and genotyped putative functional single nucleotide polymorphisms (SNPs) as well as tagging SNPs from HapMap in a Finnish case-control data set – 340 affected and 357 matched control individuals – for a genetic association study of ROCK2 in preeclampsia. Even though several new SNPs were discovered, we did not detect significant allelic or haplotypic association between ROCK2 and preeclampsia. We assessed ROCK2 expression in placentas by microarray analysis, but no significant expression differences were observed when comparing preeclamptic and normotensive pregnancies. We conclude that common genetic variation in ROCK2 is unlikely to make a major contribution to the risk of preeclampsia, but cannot exclude the possibility of having missed non-coding functional variants or rare coding variants.

Key Words: gene expression/genetic association/preeclampsia/pregnancy/ROCK2

Submitted on April 24, 2008; resubmitted on May 7, 2009; accepted on May 7, 2009.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer: Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.