The cover image shows histology of testicular tumors and testis weights from inhibin-deficient mice treated with PBS or ActRII-mFc. (A) Histopathology of a gonadal sex cord-stromal tumor from a 12-week-old inhibin-deficient male treated with PBS. Solid tumors (arrow heads) with hemorrhage (*) were formed in the control mice. Note the presence of a few seminiferous tubules (**) that were depleted of germ cells. (B) Histopathology of a gonadal sex cord-stromal tumor from a 12-week-old inhibin-deficient male treated with ActRII-mFc. Note the overall testis size is small with more seminiferous tubules (**) present. A small tumor can be found within the testis (arrow head). (C) Histopathology of a gonadal sex cord-stromal tumor from a 12-week-old inhibin-deficient male treated with ActRII-mFc. Note the presence of seminiferous tubules (**), multiple cysts (c) and a small tumor (arrow head) within the testis. (D) High power view of the tumor (arrow head) shown in (C). Note the depletion of germ cells in the tubules (**). (E) Histology of testis from a 12-week-old WT male. Note the normal tubule structure and spermatogenesis. (F) Comparison of the testis weights between the PBS (9.5-12 weeks; n = 12) and ActRII-mFc-treated (12 weeks; n = 5) inhibin-deficient male mice. Data are shown as mean ± SEM, and bars without a common letter are significantly different at P , 0.05. Scale bars: A, 200 mm; B and C, 400 mm; D and E, 50 mm (See Li et al., pp. 675-683).
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