The cover image shows immunolocalization of E-cadherin and proteins of the adhesion complex in human spermatozoa. Distribution of E-cadherin immunostaining patterns in acrosome-reacted spermatozoa. Cells were stained with anti-E-cadherin antibody (H-108) and CY3-labeled secondary antibody followed by incubation with FITC-PSA to assess the acrosomal status. E-cadherin staining patterns: a signal over the entire head (H), in the post-acrosomal region (PA) or in the equatorial segment (ES). FITC-PSA staining patterns: a ‘patchy’ signal on the acrosomal cap (p), a label in the equatorial segment (es) or no label (nl), n = 5. Representative images of the H, PA and ES E-cadherin patterns in ‘es’ acrosome-reacted cells are shown. Bar: 2.5 mm. (See Marín-Briggiler et al., 561-571).
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