The cover image shows cytogenetic analysis of 47,X,i(Xq),Y Klinefelter patient. (A) Two-colour FISH analysis on blood lymphocytes shows one signal (red) for the Y chromosome and three signals (green) for the X chromosome, two of which strictly associated. (B) BrdU replication analysis on blood lymphocyte culture. The Xq isochromosome was late replicating in all metaphases observed, suggesting a preferential inactivation. (See Stabile et al., 635-640).
[Table of Contents]